STUDY ON TARGETED DELIVERY OF 5-FLUOROURACIL FROM SUPER PARAMAGNETIC STARCH NANOPARTICLES

Abstract

This paper deals with the effects of 5-Fluorouracil drug on iron oxide impregnated starch nanoprticles and native starch used in targeted therapy. Such systems have shown potential in releasing chemotherapy drugs controllably. In the present investigation starch nanoparticles were synthesized by emulsion cross linking method and characterized by various techniques such as Fourier transform–infrared spectrometry, Transmission electron microscopy, prepared native starch nanoparticles and Superparamagnetic starch nanopartcles with the average diameter of 6nm to 80nm through W/O emulsification-cross linking method. The release behavior of superparamagnetic starch nanoparticles was studied as a function of various factors such as chemical composition of nanocareer, pH, temperature, biological fluids, applied magnetic field. The results revealed that the iron oxide loaded starch nanoparticles and native starch nanopartcles prove to be an excellent option for controlled and targeted delivery of  5 Floro Uracil by application of an external magnetic field. Therefore, there is a strong incentive to develop a new strategy for the synthesis of starch nanoparticles and research their properties.